PROTEOZ 2.5-Health29

PROTEOZ 2.5MG INJ

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₹3073.63 ~~₹3415.14~~ 10% OFF

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ZYDUS (CELEXA)

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Product SKU: PROTEOZ 2.5MG INJ*

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DESCRIPTION

Proteoz 2.5mg Injection is used in the treatment of multiple myeloma and mantle-cell lymphoma. It shows its working by stopping or slowing down the growth of cancer cells.

Mechanism of Action

• Nonsteroidal antiandrogen agent that binds to androgen receptor

and inhibits androgen uptake as well as inhibiting androgen binding

in the nuclei of androgen-sensitive prostate cancer cells.

• Affinity to androgen receptor is four-fold greater than flutamide..

Mechanism of Resistance

• Decreased expression of androgen receptor.

• Mutation in androgen receptor leading to decreased binding affinity

to bicalutamide.

Metabolism

Extensive metabolism occurs in the liver via oxidation and glucuronidation

by cytochrome P450 enzymes to inactive metabolites. Both parent drug

and its metabolites are cleared in urine and feces. The elimination half-life

is long, on the order of several days.

Indications

Stage D2 metastatic prostate cancer.

Special Considerations

1. Use with caution in patients with abnormal liver function. Monitor

LFTs at baseline and during therapy.

2. Caution patients about the potential for hot flashes. Consider the use

of clonidine 0.1–0.2 mg PO daily, megestrol acetate 20 mg PO bid,

or soy tablets one tablet PO tid for prevention and/or treatment.

3. Instruct patients on the potential risk of altered sexual function and

impotence.

4. Pregnancy category D. Breastfeeding should be avoided.

Toxicity 1

Hot flashes, decreased libido, impotence, gynecomastia, nipple pain, and

galactorrhea. Occur in 50% of patients.

Toxicity 2

Constipation observed in 10% of patients. Nausea, vomiting, and diarrhea

occur rarely.

Toxicity 3

Transient elevations in serum transaminases are rare.

USES OF Proteoz INJECTION

* Multiple myeloma

*Mantle-cell lymphoma

HOW Proteoz INJECTION WORKS

Proteoz 2.5mg Injection is an anti-cancer medication. It works by blocking or slowing the breakdown of proteins in cells. As a result, there is an increase in a number of proteins in the cancer cells leading to their death.

SPECIFICATION

MANUFACTURER

ZYDUS (CELEXA)

SALT COMPOSITION

Bortezomib (2.5mg)

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PROTEOZ 2.5MG INJ

DESCRIPTION

USES OF Proteoz INJECTION

HOW Proteoz INJECTION WORKS

SPECIFICATION

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